Similarly, in a meta-analysis of eight randomized controlled trials (RCTs) including PCOS women, Zhang et al. concluded that, based on available evidences, low-carbohydrate diets (LCD) could effectively control body weight and they could restore, at least in part, insulin sensitivity, thus counteracting glucose metabolism impairment, gonadotropin imbalance and ovarian dysfunction in PCOS patients [20]. The gene discussed is INS; the disease is polycystic ovary syndrome.