Thyroid hormone enhances intestinal absorption of glucose, glycogenolysis, and catabolism of insulin in the liver, which can lead to hypoglycemia in patients with hypothyroidism and ketoacidosis in patients with hyperthyroidism.[11,12] Subclinical hypothyroidism in patients with T1DM can lead to increased blood lipids. The gene discussed is INS; the disease is type 1 diabetes mellitus.