Diabetes mellitus is a metabolic disorder characterized mainly by the presence of chronic hyperglycemia due to a deficiency of insulin secretion or insulin resistance.[1] The International Diabetes Federation reported 425 million people globally with diabetes mellitus in 2017.[2] These figures were expected to increase to 693 million by 2045.[3] Long-term hyperglycemia can lead to a series of serious complications, such as diabetic nephropathy, diabetic peripheral neuropathy, diabetic retinopathy and diabetic foot, diabetic foot is considered to be 1 of the most serious complications. Here, INS is linked to diabetic foot.