Two meta-analysis studies showed that statins lower the rate of estimated glomerular filtration rate (eGFR) decline.[63,64] However, in a recent systematic review, statins were shown to have no significant effect on the reduction of GFR in patients with diabetes, hypertension, or glomerulonephritis; this was only observed in patients with known CVDs.[64] Several recent studies have described the effect of statins on serum C-reactive protein levels in patients with CKD. This evidence concerns the gene CRP and diabetes mellitus.