PPARA and rhabdomyosarcoma: Fibrates may affect cholesterol biosynthesis and lead to changes in the constitution and function of the muscle fibre's plasma membrane.[7] Emergence of muscle necrosis and increase in muscular lipoproteinlipase activity may also be the underlying mechanisms of fibrates-induced rhabdomyolysis.[7] It is demonstrated that fibrates can induce specific cell injury to human embryonal rhabdomyosarcoma cells through activation of peroxisome proliferator-activated receptor-α (PPARα).[8] Therefore, activation of PPARα-signaling pathway may be an important mechanism of fibrates-induced rhabdomyolysis.