SGLT-2 inhibitors reduce the reabsorption of sodium in the renal tubule, leading to mild temporary diuresis.[18] Increased glucose load in the renal tubule due to constant glycosuria causes osmotic diuresis, thereby promoting the excretion of hypotonic urine and eventually leading to dehydration and hypovolemic hypernatremia. The gene discussed is SLC5A2; the disease is Hypernatremia.