BRAF and colorectal carcinoma: In the BEACON CRC study, the median overall survival time of the three-drug regimen encorafenib (ENCO)+ binimetinib (BINI)+ cetuximab was 9.0 months (95% confidence interval, 8.0–11.4).[18] The combination of ENCO+ BINI+ cetuximab improved the OS and ORR in patients with BRAF V600E-mutant mCRC when compared with the current standard of care chemotherapy and had a safety profile consistent with the known safety profile of each agent.[18] If this procedure could have been applied early in this patient to treat subcutaneous metastases, it might have changed the outcome.