Children with hypodiploid ALL had the best prognosis, while those with IL3-IGH rearranged had the worst prognosis (5-year survival rate: TEL-AML1, 10.1%; hyperdiploidy, 19.4%; hypodiloidy, 64.7%; IL3-IGH, 0.01%; E2A PBX1, 14.2%; BCR-ABL1, 15.2%; MLL rearranged, 12.3%) (Fig. 2C). The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.