In the Han study, mice lacking TRAF6 specifically in DC exhibited spontaneous enteritis that was associated with unrestrained Th2 responses and decreased Treg numbers; importantly, DC in these mice expressed significantly lower levels of IL‐2, and the aberrant immunophenotype could be rescued by the addition of exogenous IL‐2,91 implicating DC‐derived IL‐2 in the maintenance of adaptive immune tolerance in the murine gut. Here, IL2 is linked to enteritis.