TARDBP and amyotrophic lateral sclerosis: Through these protein-nucleic acid interactions TDP-43 facilitates RNA transport (Fallini et al., 2012) and directly effects splicing of a multitude of RNAs including those coding for many ALS-associated heterogeneous nuclear ribonucleoprotein particles (Deshaies et al., 2018) and TDP-43 itself (Ayala et al., 2011).