High levels of serum IL-6, IL-8, IL-10, IL-18, CCL2, TNF-α, IFN-α, and IP-10 were detected in PM/DM-IP cases, and activated macrophages, Th1-type T lymphocytes, and neutrophils are thought to be involved in the pathogenesis [25–29]. This evidence concerns the gene IL18 and incontinentia pigmenti.