CAMT is due to MPL mutations [21], usually in the distal CRHD, while all three mechanisms are responsible for impaired MPN MPL expression [2,27,41,51]; germline SNP causing impaired MPL expression, which are also located in the distal CRHD, appear to involve impaired post-translational processing [51,52]. This evidence concerns the gene MPL and myeloproliferative disorder.