At the levels of gene expression performed in COPD samples, other circuits, namely, CSF2 and RANKL/TNFSF11, remained deactivated as evident from mega-analysis of both Top 6 and control set of datasets (LFC< 0.085), OP_COPD→Pathway_Mega. The gene discussed is TNFSF11; the disease is chronic obstructive pulmonary disease.