It was reported that tumor cells can promote the osteoclast formation through secreting a series of osteoclastogenic cytokines via a RANKL dependent or independent ways, including IL-11, VEGF, CTGF, PTHrP [34], here we found CRC cells can regulate the osteoclastogenesis via indirectly regulating the production of CCL3 through secreting EGF. The gene discussed is CCN2; the disease is neoplasm.