Low plasma concentrations of high-density lipoprotein cholesterol inversely correlate with the severity of the septic disease and associate with an exaggerated systemic inflammatory response (13); furthermore, initial low serum concentrations of Apo-A1 are poor prognostic indicators during severe sepsis, being associated with increased mortality, prolonged stay in intensive care unit, and hospital-acquired infection (14). The gene discussed is APOA1; the disease is glycogen storage disease VI.