To test the effect of silencing endothelial TGFβ signaling on atherosclerosis, Chen et al. (28) created endothelial fate-mapped mice carrying floxed TGFβR1 and TGFβR2 alleles under control of an inducible Cdh5 promoter on an ApoE−/− background. This evidence concerns the gene APOE and atherosclerosis.