CXCL8 and breast cancer: Moreover, exposure to the SCM induces senescence propagation in MCF-7 cell cultures and remarkably the secretion of the cytokines IL-6 and IL-8 by this supposedly non-secreting IL-6 and IL-8 breast cancer cell line, a phenomenon that allows reinforcement of senescence by inflammatory cytokines potentiating cellular plasticity (Ortiz-Montero et al., 2017).