CXCL8 and neoplasm: Tumour-associated macrophages (TAM) are the most abundant infiltrated leukocyte in the TME, in general they are polarized to the M2 phenotype and secrete IL-8, showing either anti- or pro-tumourigenic effects (Mantovani, 2004; Sica et al., 2006; Dominguez et al., 2017).