On the other hand, the presence of the minor IFNL3 alleles (rs12979860 T allele and others in LD such as rs12980275 G allele) are linked to the IFNL4 rs11322783 ΔG allele, which is responsible of a fully functional IFNL4 protein expression, generating another set of ISGs that could result in a risk phenotype against infection (18). This evidence concerns the gene IFNL3 and infection.