The gene expression of SMTNL1 was also significantly increased by approximately 4-fold in human cerebral arteriovenous malformations, suggesting that the elevated level of SMTNL1 may decrease MYPT1 expression to relax brain blood vessels and thus contribute to this lumen disorder (Yao et al., 2019). This evidence concerns the gene SMTNL1 and Cerebral arteriovenous malformation.