SMARCA4 and Hepatic fibrosis: Of note, it was found that primary LSECs isolated from fibrotic ecKO mice receiving CCl4 injection expressed higher levels of endothelial marker genes (Cdh5 and Pecam1) but lower levels of mesenchymal marker genes (Col1a2 and Acta2), suggesting that BRG1 might regulate liver fibrosis by promoting EndMT in vivo (Figure 3A).