In contrast, administration of either HIF-1α inhibitor attenuated CCl4-inducd liver fibrosis to a comparable degree as evident in the down-regulation of pro-fibrogenic gene expression levels (Figures 5C,D), reduction of picrosirius red and Masson’s stainings of collagenous tissues (Figure 5E), and decrease in hepatic hydroxylproline quantification (Figure 5F). This evidence concerns the gene HIF1A and Hepatic fibrosis.