We have previously shown that endothelial-specific deletion of BRG1 in mice attenuates bile duct ligation (BDL) and thioacetamide induced liver fibrosis by regulating the transcription of caveolin-1 (CAV1) (Shao et al., 2020) and NADPH oxidase 4 (NOX4) (Li Z. et al., 2019), respectively. Here, NOX4 is linked to Hepatic fibrosis.