Indeed, our recent data suggest that alleviation of unilateral ureteral obstruction induced renal fibrosis in endothelial-specific BRG1 knockout mice could be ascribed to down-regulation of adhesion molecules in the kidneys, which leads to decreased trafficking of macrophages and consequently amelioration of renal inflammation (Liu et al., 2019); a similar scenario may apply the currently investigated experimental setting. This evidence concerns the gene SMARCA4 and Ureteral obstruction.