In this case, the cancer cell crosstalk with ASCs results in constraining white adipocyte differentiation potential and stimulating proliferation (Park et al., 2011; Koellensperger et al., 2014; Freese et al., 2015; Armignacco et al., 2019), similar to the process observed following p107 suppression in fat precursors (De Sousa et al., 2014). This evidence concerns the gene RBL1 and cancer.