G0S2 and adrenal cortex carcinoma: Of note, aggressive adrenocortical cancers are often characterized by hyper-activating mutation or upregulation of Wnt/beta catenin pathways (Assié et al., 2014) and hyper-methylation/repression of the G0/G1 switch gene 2 (G0S2) gene (Barreau et al., 2013; Mohan et al., 2019).