IL4 and Alzheimer disease: The initial course of AD is characterized by a biphasic inflammation, where a Th2 profile predominates, with increased levels of several cytokines, including interleukin-4 (IL-4), IL-13, IL-17, IL-22, IL-31, and thymic stromal lymphopoietin (TSLP) (Olivry et al., 2016; Chaudhary et al., 2019).