In addition, in a phosphoproteomic screening study for PINK1 substrates, Lai and colleagues reported that the phosphorylation of Rab GTPases such as Rab8A at the conserved Ser 111 is indirectly regulated by PINK1, and this phosphorylation can block the phosphorylation of Rab8A at Thr72 by leucine-rich repeat kinase 2 (LRRK2), suggesting the interplay of PINK1 with other PD-related genes (Lai et al., 2015; Vieweg et al., 2019). Here, PINK1 is linked to Parkinson disease.