PRDM9 and colorectal carcinoma: In our study, ALKBH4 markedly suppressed EMT and CO-IP assay demonstrated that ALKBH4 directly interacted with WDR5 in CRC cells, a key component of histone methyltransferase complex, along with the decreased level of H3K4me3 histone modification (Dou et al., 2006; van Nuland et al., 2013).