AKT1 and cancer: The previous studies have shown that WDR5 is a major driver of cell progression in various cancer types (Kim et al., 2014; Chen et al., 2015; Dai et al., 2015) and its functional mechanism has been elucidated in CRC by triggering EMT process in response to the PI3K/AKT signaling pathway (Tan et al., 2017).