This study also reported that the transactivation of RAR response element could be inhibited by IGFBP-3 through the inhibition of RXR-α-RAR-α heterodimer, while the ability of all trans retinoic acid to bind with the complex was maintained, thus supporting the role of IGFBP-3 as a growth stimulator in the breast cancer cells. The gene discussed is RARA; the disease is breast cancer.