IGFBP3 and malignant colon neoplasm: The involvement of IGFBP-3 in the inhibition of cell growth is evident when human IGFBP-3 cDNA is transfected into mammalian cell lines like colon cancer cells (MacDonald et al., 1999), human breast cells (Firth et al., 1998a) and mouse fibroblast cells (Cohen et al., 1993).