IGFBP3 and metabolic disease: The pleiotropic nature of IGFBP-3, whereby, it interacts with plethora of partners is an important property possessed by the molecule that has not only provided new insights into understanding the basic mechanisms of several cellular processes but could also play an essential role in deciphering the unknown complex mechanism(s) of IGFBP-3, thus establishing it as potential targets in several diseases including cancer and other metabolic diseases.