Chronic inflammation is implicated in visceral obesity and exacerbates insulin resistance, which is characterized by the abnormal production of adipocytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), IL-6, leptin, and plasminogen activator inhibitor-1 (PAI-1) (Vaziri et al., 2005; Di Lorenzo et al., 2013). The gene discussed is SERPINE1; the disease is Insulin resistance.