TLR7 and influenza: Suggesting that the role of TLR7 and RIG-I signaling is complicated in influenza infection, Tlr7−/−Mavs−/− knockout mice succumb quickly to a lethal influenza infection as expected, however infection with a low viral dose revealed that proinflammatory signaling promoted viral replication by recruiting susceptible monocytes (Pang et al., 2013).