The association of Malassezia with AD was first based on the observation that AD patients are often sensitized to Malassezia with Th2 cells and IgE that are directed against the fungus (Scalabrin et al., 1999; Zargari et al., 2001; Johansson et al., 2002; Balaji et al., 2011). Here, IGHE is linked to Alzheimer disease.