Owing to the role of Sdc-1 and HPSE in tumor growth, invasion and metastasis we aimed at investigating the underlying molecular interplay between Sdc-1 and HPSE and the possible signaling routes in the well-established colon cancer cell line Caco2, applying both stable overexpression and transient siRNA knockdown methods. Here, HPSE is linked to malignant colon neoplasm.