Differences in the mRNA and protein expression of Sdc-1 have been noted, as Sdc-1 mRNA was strongly overexpressed in metastatic colon tumors, whereas using immunohistochemistry, metastatic tumors showed a dramatic decrease in staining, while labeling was still strong in the adjacent normal mucosa (11, 12). The gene discussed is SDC1; the disease is metastatic malignant neoplasm in the colon.