In contrast to the findings by Renz et al., which showed that Chrm1 suppresses pancreatic cancer, a study by Magnon et al. showed that stromal cells-specific Chrm1 is indeed essential for prostate cancer metastasis, indicating that Chrm1 is a potential therapeutic target for prostate cancer (10, 42). The gene discussed is CHRM1; the disease is Familial prostate cancer.