Adrβ3 signals also enrich stromal population by recruiting and maintaining hemopoietic (HSC) and mesenchymal stem cells (MSC) favoring tumor aggression, while Adrβ3 blockade was shown to promote local differentiation of HSC to lymphoid/myeloid lineages and MSC to adipocyte lineages in melanoma favoring a less aggressive tumor milieu (30). The gene discussed is ADRB3; the disease is melanoma.