SPHK2 and neuroblastoma: Adrβ3 was also shown to regulate the stemness of neuroblastoma cells wherein Adrβ3 inhibition promoted their differentiation by disrupting the sphingosine kinase 2(sk2)-sphingosine-1-phosphatase receptor 2 (S1P2) axis, which is a lipid metabolic axis otherwise crucial for these cells' stemness and proliferation (28).