Intriguingly, significantly reduced expression of ETS1 was observed in not all but specific types of cancers, including Bladder Urothelial Carcinoma (BLCA), colon adenocarcinoma (COAD), and Lung adenocarcinoma (LUAD), compared to normal specimens (Supplementary Figure 2A), which is highly correlated with poor clinical outcomes in general, consistent with BRCA (Supplementary Figure 2B). The gene discussed is ETS1; the disease is colon adenocarcinoma.