Intriguingly, significantly reduced expression of ETS1 was observed in not all but specific types of cancers, including Bladder Urothelial Carcinoma (BLCA), colon adenocarcinoma (COAD), and Lung adenocarcinoma (LUAD), compared to normal specimens (Supplementary Figure 2A), which is highly correlated with poor clinical outcomes in general, consistent with BRCA (Supplementary Figure 2B). This evidence concerns the gene ETS1 and cancer.