CD274 and cancer: In addition to inflammatory factors such as IL-10 and GM-CSF (21), other factors such as tumor cell-released autophagosomes (TRAPs) (29), long non-coding RNA HOXA transcript at the distal tip (HOTTIP) (30), and IL-6 from cancer-associated fibroblasts (CAFs) (31) have also been reported to regulate PD-L1 expression.