This has not only been demonstrated in glioblastoma but also in non-contrast enhancing low grade glioma in which IDH mutated low grade glioma (both oligodendroglioma and astrocytoma) were more frequently located in the frontal lobes, while non-contrast enhancing IDH wildtype astrocytoma were more frequently located in the basal ganglia of the right hemisphere (20). Here, IDH2 is linked to glioma.