We further evaluated the correlation between HMGA1 and miR-221 in The Cancer Genome Atlas (TCGA) database by LinkedOmics (32), in which we observed a strong and positive correlation between miR-221 and HMGA1 and a negative correlation between miR-221 and TP53INP1, HMGA1, and TP53INP1 in 402 BC tissues (Figure 4A). The gene discussed is TP53INP1; the disease is breast cancer.