For example, GLI TFs are the primary mediators of developmental Hedgehog-GLI signaling pathway, which is mostly inactive in adults (except for in stem cells) (125), but GLI inhibition was found to block EMT in pancreatic cancer stem cells through reversion of the typical EMT cadherin switch and blockade of EMT-TFs (126). Here, GLI1 is linked to pancreatic neoplasm.