In gastric cancer studies, G9a was shown to recruit p300 and GR, promoting gastric cancer metastasis by upregulating ITGB3 in a SET-domain independent manner [64] In future studies, interrogation of G9a binding to the RelB promoter region as well as identification of co-transcription factors of G9a may provide greater insight into G9a regulation of RelB. The gene discussed is EP300; the disease is gastric cancer.