Rivaroxaban was approved by the FDA in 2012 for stroke prevention in nonvalvular AF following the results of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in AF (ROCKET AF) study.25 The ROCKET-AF trial was a randomized, multicenter trial. This evidence concerns the gene F10 and atrial fibrillation.