Importantly, although LVEF < 30% was also associated with a similar risk of non-sudden cardiac death (adjusted HR: 3.5; p = 0.025), BNP had no association with non-sudden cardiac death.111 BNP levels have been shown to be strong, independent predictors of sudden death in other study populations, including post-MI and non-ischemic causes of heart failure as well.112. The gene discussed is NPPB; the disease is heart failure.