Acetyl-CoA carboxylase 1 (ACACA), fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), and the fatty acid-coenzyme A ligase family are critical enzymes in de novo fatty acid synthesis and elongation and all of them are upregulated in RA T cells as they differentiate into effector cells [68] (Figure 3). The gene discussed is ACACA; the disease is rheumatoid arthritis.