Lacking a myristate tail, AMPK cannot be recruited to the lysosomal membrane and RA T cells fail to form the v-ATPase-Ragulator-AXIN/LKB1-AMPK super-complex, where AMPKα-Thr172 is phosphorylated by LKB1 [88]. Here, PRKAB1 is linked to rheumatoid arthritis.