TARDBP and amyotrophic lateral sclerosis: Acumulations of cytoplasmic aggregates of the TDP-43 protein are foundin the SC of 90% of ALS patients [143].A study of a biological model of ALS, in which neurodegeneration was caused byTDP-43 overexpression, demonstrated only minor changes in microglia during thedevelopment of SC pathology despite the progressive loss of motor neurons.After suppression of TDP-43 expression, the number ofmicrogliocytes transiently increases.