Although restoration of SHP-1 expression induces sensitivity towards CEP-701 and could serve as a target in the treatment of AML [39], Lestaurtinib failed to demonstrate any overall clinical benefit in a phase III trial when combined with intensive chemotherapy in patients with newly diagnosed FLT3-ITD-mutated AML [25, 40, 41]. Here, FLT3 is linked to acute myeloid leukemia.