This research aimed to study the effectiveness of stimulating the DLPFC with two protocols of stimulating anodal right/cathodal left and sham Transcranial Direct Current Stimulation (tDCS) in the Dorsolateral Prefrontal Cortex (DLPFC) area to increase the BDNF and reduce the level of depression, anxiety, stress, and craving for drug taking. This evidence concerns the gene BDNF and depressive disorder.