PRKN and Parkinson disease: Resveratrol as another polyphenol compound, has also been shown with in vitro primary fibro-blasts cultures in PD patients who carry PARK2 mutations to regulate homeostasis of the mitochondrial energy due to an increase in complex I activity, citrate synthase activity, basal oxygen consumption, ATP production, and a decrease in lactate (Ferretta et al., 2014).