To gain insight into molecular mechanisms and biological pathways underlying apoA-I tumor suppressive activity, we performed whole-genome expression profiling of B16F10L homografts from A-I Tg+/–, A-I KO, and WT mice by DNA microarray technology (a total of 24,613 probes corresponding to 17,877 mouse genes were interrogated). The gene discussed is APOA1; the disease is neoplasm.