SREBF2 and liver cancer: Recently, the ATP-binding cassette transporter A1 (ABCA1), which facilitates the active efflux of lipids and cholesterol to apoA-I thereby initiating HDL biogenesis, was identified as a transcriptional target of wild-type p53, and mediator of p53 inhibition of the mevalonate pathway via SREBP-2 maturation, in a murine model of liver cancer [61].