In humans, the chromosomal locus of Phgdh (1p12) is amplified in a subset of melanoma and breast cancers (estrogen receptor-negative), and recent reports using an in vivo shRNA library screen and metabolomic profiling support the notion that increased expression of PHGDH promotes tumor growth trending with poor outcome [42, 43]. The gene discussed is PHGDH; the disease is breast cancer.