Detailed analysis of the SCL-LMO2 PPI interface, as revealed by the crystal structure of the complex, uncovered a small interface area (620 Å2) suggesting that the bulk of the binding energy is provided only by a small subset of amino acids around the hinge domains of LMO2 and that targeting this “hot spot” by small molecules is likely to destabilise this T-ALL oncogenic interaction. The gene discussed is LMO2; the disease is acute lymphoblastic leukemia.