However, OPG expression in breast cancer cells, including MCF-7 and T47D, has been shown to be associated with inhibition of TRAIL-induced apoptosis in vitro; increased proliferation via binding to various cell surface receptors; induction of angiogenesis; and paracrine regulation of non-tumoral cells in the tumor microenvironment [35]. The gene discussed is TNFSF10; the disease is neoplasm.