Overexpression of RANK in normal HR-negative MCF10A mammary cells induces stemness and transformation features, namely mammary gland reconstitution, epithelial-mesenchymal transition (EMT), increased migration, and anchorage-independent growth [13]; interfering with mammary cell commitment and contributing to breast carcinogenesis [14]. The gene discussed is TNFRSF11A; the disease is neoplasm.