Compared with those participants with a high platelet count, those with a low platelet count were more likely to have chronic kidney disease (CKD) and use non-vitamin K antagonist oral anticoagulants (NOACs) more frequently, had a higher serum cystatin C concentration, and had a lower low-density lipoprotein (LDL)-cholesterol concentration. The gene discussed is CST3; the disease is chronic kidney disease.