MIM database indicates that mutations in GNB5 are associated with autosomal recessive disorders: infantile developmental disorder with cardiac arrhythmias (IDDCA, MIM# 617173) and language delay and ADHD/cognitive impairment with or without cardiac arrhythmia (LADCI, MIM# 617182). This evidence concerns the gene GNB5 and chronic obstructive pulmonary disease.