In this study, RA induction was more pronounced in KLF2 hemizygous (KLF2+/−) mice compared to wild type (WT) animals; more ankle swelling and more severe immunohistochemical signs of inflammation and tissue damage were detected in the KLF2+/− mice, whereas WT animals showed only mild signs of arthritic pathogenesis. Here, KLF2 is linked to rheumatoid arthritis.