NLRP3 and cryopyrin-associated periodic syndrome: In particular, Q703K was found in 7% of CAPS patients from the Eurofever Registry (25); Vitale et al. (15) also demonstrated that patients carrying Q703K may present with FCAS-like symptoms, and Insalaco et al. (26) described a new CAPS phenotype associated with the combination of Q703K with a second novel mutation in the NLRP3 gene.